CovidV1, Main, Exploration, bibRecord, 000569

Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.

Identifieur interne : 000569 ( Main/Exploration ); précédent : 000568; suivant : 000570

Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.

Auteurs : Jimin Xu ; Pei-Yong Shi ; Hongmin Li [États-Unis] ; Jia Zhou

Source :

ACS infectious diseases [ 2373-8227 ] ; 2020.

RBID : pubmed:32125140

Abstract

The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved anthelminthic drug, was found to be effective against various viral infections with nanomolar to micromolar potency such as SARS-CoV, MERS-CoV, ZIKV, HCV, and human adenovirus, indicating its potential as an antiviral agent. In this brief review, we summarize the broad antiviral activity of niclosamide and highlight its potential clinical use in the treatment of COVID-19.

DOI: 10.1021/acsinfecdis.0c00052
PubMed: 32125140

Affiliations:

États-Unis

Le document en format XML

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<front><div type="abstract" xml:lang="en">The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved anthelminthic drug, was found to be effective against various viral infections with nanomolar to micromolar potency such as SARS-CoV, MERS-CoV, ZIKV, HCV, and human adenovirus, indicating its potential as an antiviral agent. In this brief review, we summarize the broad antiviral activity of niclosamide and highlight its potential clinical use in the treatment of COVID-19.</div>
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Serveur d'exploration Covid

Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.

Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.

Source :

Abstract

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Le document en format XML

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